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How does our
sense of smell work?

For everyone who loves food
No. 257Brain & BodyPart 36 of 36Inspired by RedditFact-checked Oct 14, 2026
Video2:37 · English voice (AI) · English subtitles

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Pinch your nose, pop a strawberry candy in your mouth, and chew. All you get is sweet, and a little sour. And the strawberry? Gone. Let go, and the strawberry rushes back. That strawberry flavor came from your nose.

Your tongue only knows a few things: sweet, sour, salty, bitter, and savory. Strawberry, coffee, grilled meat: that's all your nose. As you chew, the smell drifts up the back of your throat and into your nose. Pinch your nose, and that path is blocked. So how does your nose know it's strawberry? Let's follow a whiff of it inside.

Everything you smell is tiny molecules floating in the air, far too small to see. Strawberry is a whole crowd of different ones, mixed together. High up, deep inside your nose, is a small patch of moist skin. Millions of smell cells live there. Each cell sends out a few fine hairs. On those hairs are receivers, each one built to catch molecules of certain shapes.

Humans have about four hundred kinds of receivers. The odd part: each cell uses just one kind. Picture an apartment building with four hundred homes, each one expecting only a few kinds of guests. The strawberry molecules drift in and knock on a bunch of doors. Those homes switch on their lights, some bright, some just a little.

When coffee drifts in, a different set of windows lights up. Your brain doesn't check one window. It reads the pattern of lights. Four hundred windows can make more patterns than you could ever count. So four hundred receivers can tell apart far more than four hundred smells. So how does the news reach your brain? Cells with the same receiver all run their wires to the same little cluster.

These clusters sit right above your nose, at the very front of your brain. There, the pattern of lights becomes a map of bright dots. Sight, sound, and touch mostly pass through a relay station first. Smell's main route skips it, and quickly reaches the parts that handle feelings and memory. That may help explain why a smell can bring back a memory in a flash. But the evidence isn't complete yet.

So when you chew that candy, your tongue reports sweet, your nose reports strawberry, and your brain puts the two together into one flavor. Pinch your nose, and far fewer molecules reach the building. The windows stay dark, and the strawberry is just sweet. One more strange thing: these smell cells in your nose are replaced with new ones every month or two.

Most nerve cells in your body can't be replaced. These keep renewing. In your kitchen, which smell takes you straight back to childhood?

1

The strawberry candy with a pinched nose

sweet

Pinch your nose and chew a strawberry candy: just sweet and a little sour. Let go, and the strawberry comes back.

Your tongue only knows a few things: sweet, sour, salty, bitter, and savory. Strawberry, coffee, grilled meat — those come from your nose. As you chew, the smell drifts up the back of your throat into your nose. Pinch your nose, and that path is blocked.

Your nose is also why cold and warm water taste different: Why does cold water taste different from warm?

2

The path of a whiff of strawberry

① Drifts into the noseSmells are tiny molecules floating in the air. Strawberry is a crowd of different ones mixed together.
② Meets the hairsHigh up, deep in your nose, a small patch of moist skin holds millions of smell cells. Each one sends out a few fine hairs.
③ Shapes matchThe hairs carry receivers that catch molecules of certain shapes. Humans have about 400 kinds, and each cell uses just one.
④ Wires meetCells with the same receiver all run their wires to the same little cluster at the very front of the brain.
3

A building with 400 homes

Think of the 400 receivers as 400 homes in one building, each expecting only a few kinds of guests. A smell arrives and knocks on a bunch of doors. Those homes switch on their lights — some bright, some just a little.

Your brain doesn’t check one window. It reads the pattern of lights.

400 windows can make more patterns than you could count, so 400 receivers can tell apart far more than 400 smells. The finding that each cell uses just one receiver won the 2004 Nobel Prize.

4

Smell skips the relay station

Sight, sound, and touch mostly pass through a relay station in the middle of the brain first. Smell’s main route skips it and quickly reaches the parts that handle feelings and memory.

One sniff, and you’re a kid again? This shortcut may help explain why a smell can bring back a memory in a flash. But the evidence isn’t complete yet.

Smell the same thing long enough and your nose turns it down: Why does a room smell different when you come back?

5

A new batch every month or two

The smell cells in your nose are replaced every month or two.

Most nerve cells in your body can’t be replaced. These keep renewing — though more slowly as you get older.

Tongue says sweet.
Nose says strawberry.
Brain makes one flavor.
In your kitchen, which smell takes you straight back to childhood?
Made by Samshang × Maddox
Sources: Nobel Prize in Physiology or Medicine 2004 (Axel, Buck: odorant receptors and the organization of the olfactory system) nobelprize.org · Niimura & Nei 2006, Journal of Human Genetics (about 400 working odorant receptor genes in humans) · Malnic, Hirono, Sato, Buck 1999, Cell, “Combinatorial receptor codes for odors” · Wikipedia, Olfactory receptor neuron (millions of cells; renewed about every 30–60 days, slower with age) · Michigan State University open textbook, Introduction to Neuroscience, “Olfactory system” (main smell pathway bypasses the thalamus) · Scientific American, Jelly Bean Taste Test (retronasal smell)
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